The company has named Prakash Mallya -- currently Director for Intel's Datacenter Group in Asia -- to succeed Ghosh.
In an email to employees, Intel Vice President for Asia Pacific and Japan Regional Sales Group Jerry Tsao announced the change in leadership.
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"Today I am writing to share an important leadership transition for India. Debjani Ghosh has announced that she will depart Intel at the end of March. This is a decision Debjani has been considering for some time," he said.
He added that Ghosh, who is extremely passionate and committed to the Digital India vision, has decided to devote more of her time and energy to this endeavour.
Ghosh started with Intel in 1996 and has held numerous leadership roles over her 21-year career in the US-based company. She has been the Managing Director for Intel in South Asia since 2012.
"We are pleased to announce that Prakash Mallya has been named the Managing Director for South Asia. A 16-year veteran of the company, Prakash joined Intel in 2000 as Business Development Manager in India, responsible for the Financial Services segment," he said.
Over the years, Mallya has held several regional roles, most recently as Director for Intel's Datacenter Group in Asia.
"Prakash will begin his transition into the role immediately," he said.