The daily flight was launched by the airline's Executive Director, Saroj Datta, from the Mumbai International Airport this morning.
"With the introduction of the maiden service to San Francisco via Shanghai, we continue our airline's unprecendented expansion throughout North America," Datta said.
This is the fourth new long-haul route started by Jet Airways to North America in less than one year.
Jet currently operates to 60 destinations across India and overseas. New York (JFK and Newark), Toronto, Brussels, London, Hong Kong, Singapore, Kuala Lumpur, Abu Dhabi, Kuwait, Bahrain, Doha and Muscat are some of the major international destinations the airlines operate to.