The company had earlier ventured in to Malaysia in January 2016.
Commenting on the development, OYO Founder and CEO Ritesh Agarwal said: "After our successful overseas foray in Malaysia, we are now thrilled to offer OYO's hassle-free and standardised stay experience to travellers visiting Nepal."
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The company has been at the forefront of the small and budget hotels revolution in India, he added.
"We are excited with the opportunity to co-create another successful travel-and-hospitality ecosystem in Nepal," Agarwal said.
Founded in 2013, OYO currently has 7,000 hotels and 70,000 rooms in more than 200 Indian cities.