The Dow industrials fell more than 300 points on Friday on mounting fears of a global trade war following President Donald Trump's promise to impose import tariffs on steel and aluminum.
Europe promised to act firmly and China said it would defend its interests appropriately if Trump followed through with his pledge of imposing tariffs of 25 percent on imported steel and 10 percent on aluminum.
The blue-chip index turned negative for the year following the news and is now down 1.4 percent for the period.
Boeing's 3.8 percent fall weighed the most on the index as worries about higher costs troubled investors.
"The prospects of a trade war is growing and unless Trump's economic team can persuade the president to retreat from imposing tariffs, the markets would head for another melt down," First Standard Financial Chief Market Economist Peter Cardillo said.
World stocks tracked the Wall Street selloff into the close and tumbled on Friday, with investors flocking towards traditional safe havens including government bonds, Japan's yen and gold. Spot gold prices rose 0.50 percent to $1,322.76 per ounce.
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At 9:37 a.m. ET, the Dow Jones Industrial Average was down 1.14 percent at 24,327.61.
The S&P 500 fell 0.81 percent to 2,655.92 and the Nasdaq Composite slipped 0.99 percent to 7,109.78.
Eight of the 11 major S&P indexes were down, with technology index's 1.3 percent drop weighing the most.
Sectors considered safer during times of uncertainties such as utilities, telecoms and consumer staples were in favor.
Wall Street fell for the first time in 11 months in February, hit by worries that rising interest rates and bond yields would cool the economy and finally begin to draw money out of equities after an almost decade-long rally.
"The (tariff) announcement has also come at a time when investor sentiment is already fragile," Oanda Senior Market Analyst Craig Erlam wrote in a note.
"For someone so obsessed with stock market performance, he's taking a big gamble with these tariffs, the benefits of which are questionable."
J.C. Penney Co Inc shares plunged 9.2 percent after the department store chain missed same store sales estimates.
Foot Locker shares were also down 11.7 percent after the footwear retailer posted disappointing quarterly results.
Declining issues outnumbered advancers on the NYSE by 2,136 to 448. On the Nasdaq, 1,923 issues fell and 445 advanced.