In his first public remarks after the killing of Pakistani Taliban chief Hakimullah Mehsud in a US drone attack on Friday, Sharif said the days when security policies were decided through "telephone calls from abroad" are over.
Without referring to the killing of the Taliban chief, Sharif said US drone strikes violate Pakistan's sovereignty and international laws and are counter-productive to efforts to bring peace and stability to the country and the region.
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"Pakistan is faced with serious challenges both within the country and at international level. But there is hope, a hope to rise through and meet these challenges," he told a gathering that included top military officers and army chief Gen Ashfaq Parvez Kayani.
Interior Minister Chaudhry Nisar Ali Khan has blamed the US for deliberately sabotaging proposed peace talks with the Taliban by killing Mehsud. The government had begun contacts with the militants and a team of representatives was scheduled to meet the Taliban just before Mehsud was killed.
Sharif said his government is determined to end bloodshed and violence "but it cannot be done over-night, nor can it be done by unleashing senseless force against our citizens, without first making every effort to bring the misguided and confused elements of society back to the mainstream".
The government has to ensure that political parties, the military and civil society are on the same page to create an environment necessary to tackle this problem, he said.