Banks were among the decliners given that an end to US monetary stimulus could push the rupee lower, delaying any rate cuts from the Reserve Bank of India.
Foreign institutional investors have been sellers of Indian shares for five consecutive sessions, totalling Rs 289.5 crore, according to exchange and regulatory data.
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"Investors may continue to use rallies to lighten their positions ahead of Fed's decision," said G Chokkalingam, executive director and chief investment officer at Centrum Wealth Management.
However, the unemployment level in the US is still above seven per cent, so the Fed pulling out in the near future is definitely ruled out, added Chokkalingam.
The benchmark BSE index fell 0.53 per cent, or 102.59 points, to 19,223.28, retreating from its highest close in a week on Monday.
The broader NSE index fell 0.62 per cent, or 36.45 points, to 5,813.60.
The Federal Reserve is due to end a pivotal two-day meeting on Wednesday.
Markets are keenly waiting to see if Chairman Ben Bernanke comments on when and how the Fed will start reducing the third round of its bond-buying programme known as "quantitative easing".
Blue chips fell, with Larsen and Toubro ending down 1.2 percent, while Oil and Natural Gas Corporation Ltd lost 1.6 per cent.
Lenders retreated on worries volatility from a Fed decision to end QE3 could pressure the rupee, delaying any rate cuts after the Reserve Bank of India kept the key lending rate unchanged on Monday.
HDFC Bank fell 1.5 per cent, while Axis Bank declined 2.2 per cent and ICICI Bank lost one per cent.
Mahindra & Mahindra fell 0.6 percent on profit-taking after rising 4.3 per cent on Monday, after agreeing to sell a majority stake in its auto component unit to CIE Automotive SA for $116 million, while also buying a stake in the Spanish auto parts maker.
However, among stocks that gained, telecom shares rose after the new roaming regulations were seen as less stringent than expected and with a negligible financial impact, dealers said.
The Telecom Regulatory Authority of India's said on Monday it would allow carriers to offer free nationwide mobile roaming to subscribers for a fixed fee from July.
Reliance Communications jumped 11.6 per cent, while Idea Cellular rose 1.3 per cent.