Ravindra Jadeja grabbed a five-wicket haul as South Africa were bundled out for 121 in their first innings on the second day of the fourth and final Test against India at Feroz Shah Kotla Stadium on Friday.
Responding to India's first innings score of 334, South Africa batsmen failed to apply themselves as none of them except batting mainstay AB de Villiers (42) could provide any resistance.
Premier off-spinner Ravichandran Ashwin and Umesh Yadav claimed two wickets each, while pace spearhead Ishant Sharma took one.
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India, however, chose not to enforce the follow-on after reducing dismissing the tourists with a run-deficit of 213.
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Earlier, Ajinkya Rahane secured his maiden Test century at home and made 127 while Ashwin notched up a 56-run knock to the give the hosts a big total.
India took an unassailable 2-0 lead in the four-match series after comprehensively defeating the tourists by 124 runs in the third Test. With the win, India also ended South Africa's nine-year winning streak in away Test series.