The Men in Blue fans at the Wankhede stadium were disappointed after the home team lost to the proteas in an embarrassing defeat.
India was chasing a mammoth total of 438 and was all out for 214 runs.
Riding on centuries from captain A. B. de Villiers, Quinton de Kock and Faf du Plessis, South Africa went on a batting rampage as they posted a record-high total of 438 for 4 in the fifth and final ODI against India here.
South Africa, won the bilateral ODI series in India for the first time. India had levelled the series to 2-2 in Chennai.