Manchester United's 10-match unbeaten run ended as Louis van Gaal's side lost 0-1 to Southampton, who recorded their first league win at Old Trafford in 27 years to move up to third in the Premier League.
United failed to record a single shot on target and their 10-match unbeaten league run was ended.
Serbian midfielder Dusan Tadic scored the only goal of the game when he tapped in calmly from 12 yards after Graziano Pelle's effort had come back off the near post, the BBC reported.
United improved after the goal but Juan Mata missed two good chances as the club lost at home for the first time since their opening day reverse against Swansea City.
The win reaffirms Southampton's top-four credentials, as Ronald Koeman's side backed up their home win against Arsenal with another three points.
Southampton had not won at Old Trafford in the top tier since January 1988, a run stretching back 19 games, and this result was built on a 10th clean sheet in 21 games.
Even after centre-half Toby Alderweireld left the pitch injured in the first half, Southampton remained well-drilled and limited United's array of attacking talent to very few chances, the report added.