Five-time U.S. Open champion Roger Federer has entered the second round of the tournament after completing a first-round win over Australia's Marinko Matosevic.
The second seeded Swiss took two hours and 26 minutes to beat world number 76 Matosevic 6-3 6-4 7-6 (7-4), reports the BBC.
In the women's draw, Wimbledon champion Petra Kvitova and runner-up Eugenie Bouchard also won their respective first round matches.
Third seed Kvitova outclassed France's Kristina Mladenovic 6-1 6-0 and seventh seed Bouchard thumped Bulgaria's Olga Govortsova 6-2 6-1.
Eighth seed Ana Ivanovic beat American Alison Riske 6-3 6-0 in 65 minutes, while Samantha Stosur was a 6-1 6-4 winner over Laura Davis.
Men's fourth seed David Ferrer dropped a set as he beat Damir Dzumhur of Bosnia-Hercegovina 6-1 6-2 2-6 6-2.
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Meanwhile, American 13th seed John Isner overcame Marcos Giron 7-6 (7-5) 6-2 7-6 (7-2) and Sam Querrey followed his compatriot into the second round, ultimately proving too strong for Argentine Maximo Gonzalez in a 6-2 4-6 6-4 4-6 6-3 win.
Victoria Azarenka (Bel) (16) beat Misaki Doi (Jpn) 6-7 (7-3), 6-4 6-1
Gael Monfils (Fra) (20) beat Jared Donaldson (USA) 6-4 6-2 6-4.