The fifth round of matches in the La Liga kicks off with a Madrid derby on Tuesday when Atletico Madrid entertain Getafe.
Atletico will be clear favourites against Getaf after their 2-0 victory away to Eibar on Saturday that left them with nine points from their first four matches of the season, reports Xinhua.
Getafe meanwhile have just one win from their first four matches which came against Malaga on Friday.
Atletico will be able to field their attacking trident of Jackson Martinez, Fermando Torres and Antoine Griezmann, although coach Diego Simeone could also be tempted to rotate his squad, which could give Luciano Vietto a chance in attack.
Tuesday also sees Espanyol play at home to a Valencia side that has not hit its stride so far this season and which was only able to draw 0-0 against a 10-man Betis on Saturday.
Failure to win away to Espanyol would pile the pressure on Nuno ahead of his side's game against Granada next Saturday.
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Granada are also in action on Tuesday and they can increase the pressure on Real Sociedad coach, David Moyes, whose side has yet to win this season.
Real Sociedad are without goalkeeper Geronimo Rulli, who was sent off on Saturday against Espanyol.
Real Madrid face a difficult trip to play away to Athletic Club Bilbao on Wednesday, while champions Barcelona travel to play Celta Vigo, who have three wins and a draw in their opening four games of the season.