The FTSE 100 index, British benchmark stock market gauge, dropped by 1.34 percent, or 82.88 points, to 6104.11, as the US Federal Reserve's rate decision highlights weak global economy.
The Fed left the benchmark rates unchanged, due to recent financial market volatility and disappointing inflation data. Its assessment of the global economic conditions had made investors feel worried.
Most sectors of London market closed lower on Friday, with pharmaceuticals and biotechnology, real estate investment and services, real estate investment trusts sectors leading, Xinhua reported.
Glencore PLC's share price slumped by 4.65 percent topping the losers of the blue chips.
Share prices of GKN, Royal Dutch Shell, BP and Royal Dutch Shell declined by 3.93 percent, 3.80 percent, 3.54 percent and 3. 41 percent respectively.
Randgold Resources led the top gainers of the blue chips with a share price increase of 3.59 percent, followed by Fresnillo (3.39 percent), AstraZeneca (2.33 percent), Sainsbury (1.47 percent), Sky PLC (0.89 percent).
The FTSE 100 index has lost 7.04 percent so far this year.