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Environmental pollution too behind antibiotic resistance?

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IANS New York
Last Updated : Dec 25 2015 | 12:48 PM IST

Can the emergence of antibiotic-resistant bacteria be squarely blamed on the misuse and overuse of antibiotics? No, there is more to the problem than the misuse of common medications, says a University of Georgia researcher.

J. Vaun McArthur believes environmental contaminants may be partly to blame for the rise in bacterial resistance, and he tested this hypothesis in streams on the US Department of Energy's Savannah River Site.

McArthur tested five antibiotics on 427 strains of E. coli bacteria in the streams. His research team collected samples from 11 locations in nine streams, which included sediment as well as water samples.

The level of metal contamination among these locations varied from little to high.

The results revealed high levels of antibiotic resistance in eight of the 11 water samples.

The highest levels were found at the northern location of Upper Three Runs Creek, where the stream system enters the site, and on two tributaries located in the industrial area, U4 and U8.

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The level of antibiotic resistance was high in both water and sediment samples from these streams.

McArthur said Upper Three Runs Creek flows through residential, agricultural and industrial areas before it enters the SRS, so the bacteria in this stream have been exposed to antibiotics.

In contrast, U4 and U8 are completely contained within the site and have no known input from antibiotics.

McArthur conducted a second screening using 23 antibiotics on U4, U8 and U10, a nearby stream with little to no industrial impact.

"More than 95 percent of the bacteria samples from these streams were resistant to 10 or more of the 23 antibiotics," McArthur said.

These included front-line antibiotics, gatifloxacin and ciprofloxacin, which are used to treat basic bacterial infections from pink eye to urinary tract and sinus infections.

The contaminated streams U4 and U8 had the highest level of antibiotic resistance.

"These streams have no source of antibiotic input, thus the only explanation for the high level of antibiotic resistance is the environmental contaminants in these streams -- the metals, including cadmium and mercury," McArthur said.

The study was published in the journal Environmental Microbiology.

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First Published: Dec 25 2015 | 12:36 PM IST

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