Kyrgyzstan Prime Minister Temir Sariyev verbally tendered his resignation at a cabinet meeting on Monday, Xinhua cited the government press service as saying.
The announcement came after several parliament members accused Sariyev's cabinet of corruption.
"I will fight until my innocence is proved," Sariyev told the meeting, adding that he will demand an objective investigation into the case.
Sariyev was sworn in as prime minister in May 2015, two weeks after his predecessor, Joomart Otorbayev, stepped down.