He has submitted his resignation to Rajya Sabha Chairman, sources in TMC said.
Mithun, whose alleged involvement in Saradha scam made news in 2015, had attended the Upper House for three days only.
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He has written to the Chairman that because of his health condition he is not been able to fulfil his duty in Rajya Sabha and that is why he is relinquishing his seat, sources added.
Chakraborty was elected to the Rajya Sabha in April 2014.