Calls are mounting in Ukraine to put Yanukovych on trial, after a tumultuous presidency in which he amassed powers, enriched his allies and cracked down on protesters.
Anger boiled over last week after snipers attacked protesters in the bloodiest violence in Ukraine's post-Soviet history.
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The turmoil has turned this strategically located country of 46 million inside out over the past few days, raising fears that it could split apart.
The parliament speaker is suddenly nominally in charge of a country whose economy is on the brink of default and whose loyalties are torn between Europe and longtime ruler Russia.
The acting finance minister said today that the country needs USD 35 billion to finance government needs this year and next and expressed hope that Europe or the United States would help.
Ukraine's acting interior minister, Arsen Avakhov, said on his official Facebook page today that a warrant has been issued for the arrest of Yanukovych and several other officials for the "mass killing of civilians."
At least 82 people, primarily protesters, were killed in clashes in Kiev last week.
Avakhov says Yanukovych arrived in Crimea yesterday, relinquished his official security detail and then drove off to an unknown location, turning off all forms of communication. "Yanukovych has disappeared," he said.
Earlier, after signing an agreement Friday with the opposition to end a conflict that had turned deadly, Yanukovych had fled the capital of Kiev for eastern Ukraine. Avakhov said he tried to fly out of Donetsk but was stopped, then went to Crimea.