Police officers from China, Hong Kong, Macau, Malaysia, Singapore and Vietnam conducted more than 1,000 raids on illegal gambling dens in the six-week operation.
Many of these were operated by organised crime gangs and believed to have handled 2.2 billion USD worth of bets, mostly through illegal websites.
The operation lasted from June 1 to July 13.
"The results ... Are significant in relation to the volume of bets being handled by these illegal gambling dens, as well as the number of arrests," said Jean-Michel Louboutin, Interpol's executive director of police services.