One woman was killed in police firing and 50 other protesters were injured.
However, a section of the Pakistani media put the death toll at seven, although the figure could not be confirmed.
Police opened fire and used tear gas and lathicharged the protesters led by Imran Khan and Tahir-ul-Qadri, which had laid seige to key buildings such as the National Assembly and Supreme Court since August 14 suddenly used cutters to penetrate barbed wire barricades.
As tension mounted, Sharif left for Lahore. A late night government announcement categorically ruled out Sharif's resignation.