Clooney, 53, is business partner with founder of Casamigos Tequila, Rande Gerber, who was photographed loading 100 cases of the brand's award-winning Blanco, Reposado and Anejo tequila onto a jet headed from California to Italy, reported People magazine.
Clooney and Alamuddin, 36, are frequent companions of Gerber and his wife, model Cindy Crawford, they vacationed together in Los Cabos, Mexico, during the holidays last year and the 'Gravity' star and his fiancee celebrated their engagement at Gerber's Cafe Habana in Malibu in May.