A microbus collided with a private vehicle on Sohag-Red Sea Road, about 100 kilometers from Sohag, killing 11 people on the spot.
Fourteen people critically wounded in the accident were rushed to a local hospital by six ambulances, local media reported.
Egypt has one of the world's highest accident rates owing to careless driving and poor road and vehicle conditions.
The WHO ranks Egypt as the world's tenth worst country in terms of road accidents, after India, China and the US.