The accident occured when one the tyres of the car, proceeding from Visakhapatnam towards Tuni, suddenly burst on the National Highway (NH)-16.
As a result, the driver lost control over the vehicle and hit a motorcycle and pushed it under a lorry coming from the opposite direction, an official statement issued by the Andhra Pradesh Information and Public Relations Department said, adding that some of the bodies got crushed beyond recognition.
A father-son duo riding the bike and nine of a family travelling in the car were killed on the spot.
The father-son duo on the motorbike belonged to S Rayavaram mandal in the district and the father was identified as an employee with Hetero Drugs, the release said.
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The bodies were shifted to the government hospital in Nakkapalli for postmortem.
Andhra Pradesh Chief Minister N Chandrababu Naidu, Deputy Chief Minister N China Rajappa and Leader of Opposition Y S Jaganmohan Reddy expressed grief over the tragedy and conveyed their sympathies to the bereaved families.