Senior NDMA officials said heavy rains and flooding had caused havoc in the provinces of Khyber-Pakhtunkhawa, Punjab and Balochistan.
"In two weeks, the heavy rains have affected more than 300,000 people who have been displaced while around 110 people have died in the flooding and other incidents caused by the rains," an official said.
He said around 770 villages had been hit by the rains while flooding had destroyed 2,427 houses across Pakistan.
The rains also led to widespread problems in the urban areas with major cities like Karachi, Lahore and Rawalpindi facing flooding.
In Karachi, the heavy rains last week caused widespread damage in which around two dozen people were killed.
More than 1,800 people were killed and 21 million affected in 2010 floods in Pakistan.