"Today thugs crashed a car into the public security building of Kargilik county in Xinjiang's Kashgar prefecture and set off an explosion. Police took decisive action and shot dead 13 thugs," the official Tianshan web portal reported.
Police shot dead 13 attackers while three policemen were injured, the state-run Xinhua news agency reported.
The report described those killed as "mobsters".
Xinjiang is restive for the past several years over native Uygur Muslim's agitation, opposing settlements of Hans from other provinces.
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There have been several blasts and knife attacks in China recently.
At least 39 people were killed and 94 others injured in May in China's bloodiest terror attack at a busy market in Urumqi, provincial capital of the Xinjiang province, when militants rammed two explosive-laden vehicles into a crowd and set off over a dozen blasts.
This attack is regarded as the worst violence in the country as militants, earlier largely confined to knife attacks, used multiple explosives besides triggering car bombs.
That attack was blamed on radical religious extremists seeking to take control of the region.
While in March, knife-wielding attackers stabbed 29 people to death at another railway station in southwestern Kunming city.
Earlier this month China sentenced 81 people, including 9 persons to death, and arrested 29 others for terrorism-related crimes in the troubled Xinjiang province as part of a nationwide crackdown on Islamist militants.
China has launched a nationwide crackdown on militants from Xinjiang and also firmed up plans with Pakistan to stop infiltration of ETIM militants from across the border of Pakistan-occupied Kashmir (PoK).