The bus was carrying a marriage party. The mishap took place this morning when it was on its way to Parasia from Indore, Sohagpur Police Station in-charge Siddharth Singh said.
"15 people were killed in the mishap and 38 seriously injured. They were admitted in a private hospital at Bhopal and Hoshangabad respectively," Hoshangabad Division Commissioner V K Batham told PTI.
The bus was crossing a river bridge near Longabanjari village about 7 kms away from Sohagpur when the incident happened.
Expressing grief over the mishap, Madhya Pradesh Chief Minister Shivraj Singh Chouhan announced a relief of Rs 1.5 lakh each to the kin of deceased, Rs 50,000 to those seriously injured and Rs 25,000 to those who suffered minor injuries in the accident.
Hoshangabad Collector Sanket Bhondve and other senior officials reached the spot soon after the mishap to supervise the rescue operation.