The quake's epicentre was located near Jurm in northeast Afghanistan, 250 kilometres from Kabul and at a depth of 213.5 kms, according to the US Geological Survey.
The temblor collapsed buildings, triggered landslides and stampedes, prompting the government to rush army personnel to the affected areas for rescue operations.
Pakistan army chief General Raheel Sharif flew to some affected areas of Khyber Pakhtunkhwa to assess the rescue operation in the region that is the worst hit.
The death toll in Khyber Pakhtunkhwa province and Federally Administered Tribal Areas (FATA) is 140, with 5 killed in Punjab, 4 in the PoK, 3 in Gilgit Balitistan, several local media reports said.
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Some other media outlets put the death toll at 165 though they did not give area-wise details about the casualties.
Over 1,000 people were injured, 956 in Khyber Pakhtunkhwa alone. Malakand Division in the province is the worst hit with 74 dead.
Bajwa also said that Quick Rapid Forces (QRFs) have spread out in respective areas.
"QRFs are busy in rescue work mainly in Malakand, Dir, Chitral and Bajaur while continuous damage assessment is under way," he added.
The Provincial Disaster Management Authority (PDMA) has directed the district administration to utilise rescue and relief funds. Emergency has been declared in all government hospitals and food and necessary items were dispatched to the affected areas.
Reportedly, several buildings collapsed in various areas of the province mostly in northern parts in Chitral, Swat, Shangla, Dir and Buner districts of Khyber Pakhtunkhwa.
Several landslides have been reported in mountainous areas of the country, leading to fears that the death toll may increase.