"We have recovered 16 bodies and another 15 people were injured," police officer Jose Paredes told AFP yesterday from Huancavelica, the region in Peru's Andean south.
The cause of the latest deadly crash was under investigation, Paredes said.
On July 1, a bus fell into a ravine outside the capital Lima, killing 19 and injuring 15.
Highway fatalities occur regularly in the Andes, where crowded buses travel along narrow, twisting and ill-paved roads.