The accident took place when two trucks and a microbus collided at a road between Sohag and the Red Sea governorate late yesterday.
The injured were referred to five different hospitals, The Cairo Post reported.
An investigation into the crash has been opened and three drivers have been questioned so far, it said.
Road accidents, which official statistics say claim 18 lives a day, are common in Egypt due to ill-maintained roads as well as disregard for traffic laws.
The WHO ranks Egypt as the world's tenth worst country in road accidents.