The two men, aged 30 and 41, were led off the Pakistan International Airlines Boeing 777 by armed police officers after it was diverted yesterday en route to a scheduled landing at Manchester Airport following a disturbance in the cabin.
Superintendent Darrin Tomkins of Essex Police said a threat was made as the plane, flying from Lahore with 297 passengers on board, was preparing to land.
He confirmed that the arrested men are being questioned by detectives at a local police station in Essex, north-east of London.
RAF Typhoon fighter jets were scrambled when Flight PK709 sent out an emergency code which alerted the ministry of defence (MoD) and the police.
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A PIA spokesperson said air traffic controllers in Manchester contacted the pilot 25 minutes before the plane was due to land, after receiving information from British security services.
The aircraft then headed back out to the North Sea before travelling south to Stansted, escorted by Typhoon jets from RAF Coningsby in Lincolnshire.
"There was a conflict between two passengers after one of them got into a confrontation with the stewards. The two middle-aged passengers who previously had the altercation were simply asked to come with police who had boarded the aircraft. They were then handcuffed and taken away," passenger Shahid Yaqoob told Pakistan's 'Express News'.