The incident took place in Chandanpur village under Rasagovindapur range of Baripada forest division when the jumbo attacked the thatched house of Rama Murmu late last night killing his son Phago (7) and daughter Rukmani (12), Divisional Forest Officer (DFO), Baripada, Sanjay Swain said.
Rama's wife and two other daughters aged about 8 months and 10 years were injured in the attack, while Rama escaped unhurt, he said.
The injured were being treated at Baripada district headquartrers hospital, Swain said.
The killer elephant has been spotted at Suliapada reserve forest bordering Mayurbhanj and West Bengal after the incident, Swain added.