The clashes started after Tehrik-e-Insaf chairman Khan and Awami Tehrik chief Qadri yesterday ordered their hundreds of supporters to shift the protest venue in the front of the residence of Prime Minister Sharif to force him to quit.
Police fired tear gas shells and rubber bullets to disperse the protesters outside the prime minister's official residence and the adjacent parliament building.
Hundreds of protesters entered the lawn of parliament but they were pushed back at the main entrance of the building where army was deployed.
A police official said over 70 policemen and five Frontier Constabulary personnel were injured in clashes with protesters armed with sticks, catapults and stones.
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Dr Ayesha Isani of the Pakistan Institute of Medical Sciences hospital told reporters that a man brought to the hospital late last night had passed away.
She confirmed that earlier a man was brought dead to the hospital who had drowned by falling into a trench.
So far the protesters failed to break into the security cordon and reach the PM House.
His party leader Pervaiz Khattak said that they will not stop until Sharif resigns, as the protest entered 18th day.
Qadri today emerged from his container and addressed the supporters in husky voice which he said was due to effect tear gas. "I salute my sons and daughters who won today," he said without explaining.
He promised to make another speech later on and vowed to continue to struggle till final victory of "revolution".