Asad Usman, a senior professor of medicine, was gunned down also in Nazimabad area, police said.
"Usman was working at the Abbasi Shaheed Hospital and was shot dead by unknown assailants. His guard also fired back but he was also injured," a doctor said.
A number of intellectuals and activists have recently been targeted in the city.
In another incident, a man was killed when a bomb fixed underneath his car exploded in North Nazimabad area.
Another man was also injured in the blast.