Mirza Yousuf, a central leader Majlis Wahdatul Muslimeen, escaped the apparent sectarian attack in the city's Gulistan-e-Jauhar area. One of his bodyguards and a policeman were killed while one of his aides sustained injuries, they said.
Motorcycle-borne attackers fled away from the site.
"It is apparently a sectarian attack but Mirza Yousuf escaped unhurt since he was not riding in the car on which the two gunmen opened fire," a police official said.