One of the cubs died at around midnight yesterday and the other succumbed this morning, Bandhavgarh Tiger Reserve's field director Mridul Pathak said.
Both the cubs were four months' old.
They were among the three cubs found on January 22 this year at Sarwahi village on the periphery of the Sanjay Gandhi Tiger Reserve in the state.
The poachers had killed the mother of the cubs.
Later, the three cubs were shifted to Bandhavgarh Tiger Reserve to be put in foster care, he said.
The third cub also has the infection and a team of doctors is trying to save the feline, he added.
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