A spokesman for the rangers said that Saeedullah and Azam Mehsud were killed during an exchange of fire in Manghopir area.
"A operation was conducted in the area on a tip-off and we seized pistols and hand grenades during the raid besides various identity cards," he said.
On November 13 last year, the rangers had killed three militants of the TTP in the Landhi area.
While on October 2, security forces killed six TTP militants during two encounters and claimed to have recovered a huge cache of weapons and 200 kgs of explosives.