The incident occurred in Mastung district when a Balochistan Constabulary vehicle was on a routine patrol in Splanji area and suddenly came under attack from nearby mountains, the Dawn reported.
"Several personnel were injured in the attack," a security official said.
No one has claimed responsibility for the attack.
The rescue teams rushed to the accident site and shifted the injured to a hospital in Quetta, the provincial capital.
Baloch nationalists often target the security forces and want control over mineral wealth of the province.