The gunmen fired on police headquarters in the city of Pozanti, sparking clashes which left two police as well as two militants dead, Anatolia said, quoting top local officials.
The police were hunting for those attackers who escaped, it added.
The attack is the latest to be blamed on the outlawed Kurdistan Workers Party (PKK) which is engaged in an escalating cycle of violence with the security forces.
The military has been carrying out daily air raids on the group's camps in northern Iraq for the past few days.
According to an AFP tally, at least 13 members of the security forces have been killed in attacks blamed on the PKK since the current crisis erupted last week.