OU, celebrating its centenary this year, is hosting the Congress for the sixth time, after the ones in 1937, 1954, 1967, 1979 and 1998, noted its Vice-Chancellor, Prof S Ramachandram.
General President of Indian Science Congress Association (ISCA) Prof Achyuta Samanta said around 25,000 people are expected to attend the event.
"It is likely that around 25 Nobel laureates will speak on the occasion", Prof. Ramachandram told reporters here.
The Indian Science Congress, the country's oldest and biggest science meet, is traditionally inaugurated by Prime Minister.