The bomber struck as hundreds of people, including top police officers of Balochistan province, were attending the funeral of police station chief Mohib Ullah, who was gunned down this morning.
The attacker detonated his explosive vest when he was stopped by guards at the gate of a mosque within the Police Lines in Quetta, the capital of Balochistan.
"It was a suicide attack and the attacker blew himself up at the entrance where he was intercepted by the policemen on duty," City police chief Mir Zubair said.
Deputy Inspector General of Police Fayyaz Sumbol, Superintendent of Police Ali Mahar and a Deputy Superintendent of Police Shams-ur-Rehman were among the dead, officials said.
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Around 300 senior and lower rank police officials and local people were present for the funeral when the suicide attack took place.
"It is a major attack on the police and at least eight kilograms of explosive device was used in the suicide attack," Zubair said.
The provincial police chief and city police chief had a narrow escape. Several children were among the injured.
The victims were taken to a military hospital due to fears that civilian hospitals might be attacked. After a recent bombing at a women's university in Quetta, militants attacked the hospital where the injured were taken.
The number of casualties in the attack are expected to raise as condition of some of the injured was critical, doctors said.
Earlier in the day, police station chief Mohib Ullah was killed and his four children and a driver were injured when unidentified gunmen attacked his car at Alamu Chowk in Quetta.
No group claimed responsibility for both attacks. Several militant groups, including the Taliban and Lashkar-e-Jhangvi, are active in Balochistan.