"More than 70 per cent of the civilians were killed in regime and Russian air strikes, or in air raids of the international coalition" fighting the Islamic State group, the Britain-based monitor's head Rami Abdel Rahman said.
Backed by Russian air strikes, the forces of Syria's President Bashar al-Assad are pressing a battle to retake IS- controlled areas in the eastern province of Deir Ezzor.
A US-led international coalition has been providing air support to a Kurdish-Arab alliance also fighting the jihadists in its former northern bastion of Raqa city and Deir Ezzor.
The 955 civilians killed in September included 207 children, said the Observatory, which relies on a wide network of sources inside Syria for its information.
It said 738 jihadists -- from IS and a group led by Al- Qaeda's former Syria affiliate -- also died.
Syria's conflict has killed more than 330,000 people and displaced millions since it broke out in 2011 with the brutal repression of anti-government protests before evolving into a complex war drawing in world powers.