The mishap took place at around 6.20 AM when 12618 Nizamuddin-Ernakulam Lakshadeep Mangala Express train was passing through the Ghoti-Igatpuri section, about 35 kms from Nashik, a spokesperson of the Central Railway (CR) said in Mumbai.
While three passengers were killed in the mishap, 37 others sustained injuries and have been admitted to different hospitals, railway sources said.
Two of the deceased have been identified as - Rahul Kushwaha (31) from Aligarh and Satbir Singh from Haryana.
CR sources said that out of the 23 injured, 7 were admitted in Nashik Civil Hosptial, 3 at Vakratunda Hospital in Nasik, 2 in Gramin Hospital at Ghoti and 11 were being treated for minor injuries.
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Around 450 passengers were brought by buses from the derailed site to Igatpuri Station. A special train carrying Mangala Express passengers had left Igatpuri for Ernakulam and would halt at Kasara.
The cause of the accident is yet to be ascertained, a CR official said.
The Central Railway has set up a helpline number for inquiries from anxious relatives and kin of the passengers, the official said.
Following the mishap, rail traffic on the up side was affected, forcing railway authorities to cancel various trains, including 12109 and 12110 Godavari Express, 22101 and 22102 Rajya Rani Express, 51153 and 51154 Bhusaval-Mumbai Passenger and 17618 Tapovan Express, railway sources said.