The bus was carrying 40 passengers who are members of Colonial Hill Baptist Church and were returning from camp when the crash happened Saturday afternoon.
Indianapolis Fire Department spokesman Capt. Rita Burris confirms the deaths and says survivors were being taken to area hospitals. Those injured include children and adults. Some of the victims were taken from the scene by helicopter.
An Indiana Department of Transportation camera showed the bus overturned on its side. Roads near the scene were closed, and hazardous material crews were in the area cleaning up diesel fuel that spilled.