The mishap took place in the city's Tejaji Nagar locality on Khandwa road when the loading vehicle, carrying members of a marriage party, was returning here from Omkareshwar, they said.
The deceased in the mishap were identified as - Pramila (60), Pitambar Patel (65) and Anar Singh (45), the truck driver.
Singh was apparently standing at the rear end of the truck when the loading vehicle rammed into it.
The injured have been admitted to hospital, police said, adding that a case has been registered in connection with the accident.