Several people were also reported injured in the strike at Angar Kalli village near Miramshah Tehsil in North Waziristan last night, local media reports said today.
The identity of those killed or injured could not be ascertained.
The reports said that drones had been hovering over the area for hours.
The attack comes at a time when the Pakistan Tehreek-e-Insaf-led government in Khyber-Pakhtunkhwa has taken an increasingly anti-drone stance with regular sit-ins being organised to stop NATO supplylines.
On November 21, a US drone strike in the Tal area of Khyber Pakhtunkhwa's Hangu district had killed at least six people, all Afghan linked to Haqqani terror network.
The attack had come a day after Prime Minister Nawaz Sharif's Adviser on Foreign Affairs and National Security Sartaj Aziz said the US had assured Pakistan of not conducting drone strikes targeting the leaders of TTP if dialogue began between them and the Pakistani government.