The nationalities of the victims could not immediately be ascertained though media reports said most of the passengers were Malaysians and some were believed to be from the Middle East.
The accident occurred on a steep and winding road when the bus carrying 49 passengers was going from Genting Highlands to Kuala Lumpur. Further details were awaited.
The injured were taken to nearby hospitals.
Genting Highlands, about an hour's drive out of Kuala Lumpur, has a sprawling hotel, amusement park and a casino. It is a popular destination for almost all tourists visiting Malaysia.