Among those indicted by a Fulton County, Georgia, grand jury was Beverly Hall, the former schools superintendent who gained national recognition in 2009 for turning around Atlanta's school system.
"She was a full participant in that conspiracy," Fulton County District Attorney Paul Howard told reporters during a news conference announcing the charges.
"Without her, this conspiracy could not have taken place, particularly in the degree in which it took place."
Among those also indicted were four of Hall's executive administrators, six principals, two assistant principals, six testing coordinators, 14 teachers, a school improvement specialist and a school secretary.
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The indictment, released on Friday, follows a state investigation that was launched after a series of reports by The Atlanta Journal-Constitution newspaper found large, unexplained gains in test scores in some Atlanta schools.
A state review determined that some cheating had occurred in more than half of the district's elementary and middle schools, CNN reported.
Hall has denied any role in the cheating scandal. She resigned from her position in 2011 following the state investigation, which lambasted her leadership and found widespread cheating in dozens of Atlanta schools.