The suicide bomber blew up his explosives-laden car near Inspector General of Police Ehsan Mehboob's office in Quetta, the capital of the Balochistan province, killing at least 13 people, including seven policemen, and wounding 21 others.
The blast was claimed by both the local affiliate of the Islamic State terror group and by Jamaat-ul-Ahrar (JuA), a splinter group of the Tehrik-e-Taliban Pakistan.
Hours later, two back-to-back blasts tore through a market crowded with the people shopping for Eid in the Shia- dominated city in the Kurram tribal region, killing at least 25 people, mostly Shias, and injuring 100 others.
The first blast occurred during rush hour in Turi Market, where a bus terminal is also located, in Parachinar area. The second blast took place as rescuers and bystanders rushed to aid those who had been hurt in the first explosion.
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Medical Superintendent of the District General Hospital, Parachinar, Sabir Hussain, said that at least 25 people are killed and over 100 others injured in the blasts.
No group claimed responsibility for the blasts. However, Sunni militant groups have claimed responsibility for several attacks in the area in the past.
Officials said the blasts targeted people shopping in the area and those heading out of the city ahead of Eid.
The emergency and rescue services shifted injured to Agency Headquarters hospital Parachinar.
The security forces cordon off the entire area and started search operation.
Pakistan Army contingents and FC personnel reached the site of the attack to aid in rescue efforts.
"Two Army aviation helicopters have taken off from Peshawar to Parachinar for the speedy evacuation of the injured to Peshawar," the army said in a statement.
On March 31, a car bomb blast near an Imambargah of Shia Muslims killed 23 people and injured 70 others in Parachinar.
In January, 25 people were killed and 87 others when a bomb tore through a crowded vegetable market in the same city.
Prime Minister Nawaz Sharif condemned the attacks, saying that terrorists involved in the attacks will be taken to task and all out efforts will be taken to eliminate terrorism.
President Mamnoon Hussain, Senate Chairman Raza Rabbani, Punjab Chief Minister Shehbaz Sharif, Governor Balochistan Muhammad Khan Achakzai and former president Asif Ali Zardari, among others, also condemned the attack.
Of the injured, nine are said to be policemen.
Kakar blamed India for the Quetta blast.
DIG Quetta Abdul Razzaq Cheema, addressing the media, said they are examining CCTV footage to determine the details of the incident.
Officials said body parts of the suspected bomber, strewn across the site of the blast, were being collected along with other evidence for forensic examination.
An initial investigation report by Civil Defence Director Aslam Tareen revealed that 75 kilogrammes of explosives were used in the Quetta blast.
Officials said the explosion was loud enough to be heard from a distance and shattered windows of nearby buildings.
Earlier this year, on February 13, a blast took place near the Saryab Bridge in Quetta killing two personnel of the bomb disposal squad and leaving 11 injured.
Later in March, an explosion targeting a security forces convoy occurred on Saryab Road. Four people were injured including three Frontier Corps personnel and a passer-by.
In August, last year, a suicide bomber targeted the emergency services ward at Civil Hospital, following the death of the president of the Balochistan High Court Bar Association, killing at least 70 people and leaving many wounded.