The army was called out to support relief work in Karachi, where 10 people died. Five persons, including three children, were electrocuted while a woman drowned after falling into an open manhole, officials said.
Parts of Khyber-Pakhtunkhwa, Gilgit-Baltistan, Pakistan-occupied Kashmir and the tribal belt were also affected by rains, with 13 reported dead and 34 injured in separate incidents since yesterday. Six deaths were reported in Punjab.
Four members of a family were killed in Kurram tribal region when the wall of a house collapsed. Deaths were also reported at Peshawar and Chitral in Khyber-Pakhtunkhwa.
The Met Office said 115 mm of rain was recorded in Karachi. Commissioner Shoaib Ahmed Siddiqui said an emergency had been declared in the city.
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"We are carrying out emergency relief work in many parts of the city and the government has sought the army's support, mainly in low-lying areas like Lyari and Malir," a Karachi city administration official said.
An official of the Karachi Electricity Corporation said at least 400 feeders had tripped or been damaged by the rains which continued throughout the day.
Ahmed said his residential block had been without electricity for the past 10 hours and there was no sign that power supply would be restored soon.
Extensive property damage was reported from Pakistan's northern regions and residents in many areas were forced to leave homes inundated by rainwater.