The groundbreaking work, led by Swansea's Morriston Hospital surgeon Adrian Sugar, is being done on a man whose face was crushed in a motorbike accident.
Sugar and his team have used images from a CT scan to design bespoke devices that are being created in titanium using 3D printing.
"The patient suffered trauma and had multiple injuries across his body, including some quite severe facial injuries," Abertawe Bro Morgannwg University Health Board (ABMU)'s Maxillofacial Laboratory Services Manager, reconstructive scientist Peter Evans, said.
Sugar and Evans worked with National Centre for Product Design and Development Research (PDR)'s Sean Peel and Ffion O'Malley to virtually plan the complex surgery, which will involve repositioning the patient's facial bones.
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They worked from a CT scan that allowed them to create a mirror image of the unaffected side of the patient's face.
From this they designed guides to cut and position the bones with pinpoint accuracy, as well as implants tailor-made for the patient.
"We have done everything up the point of surgery. The concept of the operation has been virtually designed and we hope to do the work very soon," Evans said.
"The patient's facial symmetry will be restored so he should be back to normal as far as his facial looks are concerned," said Evans.