According to officials, house owner Zubair Ahmed lived along with wife and four children in the two-storey home in Farooq Gang area in Lahore.
The roof of the house caved in last night, trapping Zubair's wife and four children under the debris.
Rescue teams found Zubair's wife and four children from the debris and rushed them to a nearby hospital where they were declared brought dead.
Zubair was not present at the house when the incident took place.
Punjab Chief Minister Shahbaz Sharif has expressed his sorrow over the incident and ordered inquiry into the matter.