The four have been identified as Sukhvinder Singh, Lakhvir Singh, Major Singh and Jagdish Singh, they said.
Before escaping from the centre last night, the addicts thrashed the security guard and locked him in the bathroom, police said.
A case has been registered in this connection and a search is on to nab them.
The youths were undergoing treatment at the centre for the past one month, they said.